Archaea as a Model System for Molecular Biology and Biotechnology
Created March 18, 2026
Updated on March 25, 2026
approved
Tags:
Basic
Language
English
MainTitle
Archaea as a Model System for Molecular Biology and Biotechnology
Original ids
10.3390/biom13010114; 36671499; PMC9855744; 11588/910120; 20.500.14243/471702
Type
publication
bestAccessRight
OPEN
countries
Italy
Creator/Author
Full name
Federica De Lise, orcid: 0000-0002-9614-9226 ; Roberta Iacono, orcid: 0000-0002-3586-4322 ; Marco Moracci, orcid: 0000-0002-9846-2531 ; Andrea Strazzulli, orcid: 0000-0002-9690-149x ; Beatrice Cobucci-Ponzano, orcid: 0000-0002-8211-2297
Other
Description
<jats:p>Archaea represents the third domain of life, displaying a closer relationship with eukaryotes than bacteria. These microorganisms are valuable model systems for molecular biology and biotechnology. In fact, nowadays, methanogens, halophiles, thermophilic euryarchaeota, and crenarchaeota are the four groups of archaea for which genetic systems have been well established, making them suitable as model systems and allowing for the increasing study of archaeal genes’ functions. Furthermore, thermophiles are used to explore several aspects of archaeal biology, such as stress responses, DNA replication and repair, transcription, translation and its regulation mechanisms, CRISPR systems, and carbon and energy metabolism. Extremophilic archaea also represent a valuable source of new biomolecules for biological and biotechnological applications, and there is growing interest in the development of engineered strains. In this review, we report on some of the most important aspects of the use of archaea as a model system for genetic evolution, the development of genetic tools, and their application for the elucidation of the basal molecular mechanisms in this domain of life. Furthermore, an overview on the discovery of new enzymes of biotechnological interest from archaea thriving in extreme environments is reported.</jats:p>
Publication Date
2023-01-06
Publisher
MDPI AG
Subjects
0301 basic medicine; recoding; 0303 health sciences; Bacteria; archaea; archaea; hyperthermophiles; recoding; molecular biology; CAZymes; metagenomic; Review; Euryarchaeota; Microbiology; Archaea; QR1-502; 03 medical and health sciences; molecular biology; metagenomic; hyperthermophiles; Molecular Biology; CAZymes; Biotechnology
isGreen
true
isInDiamondJournal
false
Publication
Name
Biomolecules
Publication
Article
Starting page
114
issnOnline
2218-273X
vol
13
Other Research Product
Detailed informations
system:type
Research Product
Management Info
Author
Last Updated
March 25, 2026, 10:43 (UTC)
Created
March 18, 2026, 23:30 (UTC)
Data and Resources
This item has no data
To access the resources you must log in
